A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters.
نویسندگان
چکیده
A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry and suggest the method could be a valuable tool for chemical biology studies of proteins.
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عنوان ژورنال:
- The Journal of organic chemistry
دوره 74 23 شماره
صفحات -
تاریخ انتشار 2009